The ScopeM platform of ETH Zurich has selected Re-scan Confocal Microscopy integrating RCM with a super resolution STORM microscope

The Scientific Center for Optical and Electron Microscopy (ScopeM) is a central scientific technology platform of ETH Zurich providing resources and services in light and electron microscopy as well as direct access to state-of-the-art microscopy and sample preparation equipment. Specifically, ScopeM offers a wide range of advanced light microscopy techniques, super resolution and confocal. They have recently integrated the re-scan confocal module from to their super resolution STORM microscope. With this combination, they have the possibility to perform a fast, high resolution confocal image followed by a super-resolution (based on localization microscopy) image on the same region of interest in a specimen.

Dr Dorothea Pinotsi is a staff scientist specialising in single-molecule, super resolution and spectroscopy applications. She describes their interest in applying confocal microscopy. “There is a wide range of life science projects where confocal microscopy is beneficial. We are an open, multi-user core facility which provides both high-end equipment and expertise. Our interest in the Re-scan Confocal Microscope (RCM) from stemmed from the fact that it is a novel type of confocal microscope not only using a camera-based detection scheme, but also offering high resolution, together with high Signal to Noise ratio which is generally challenging especially in dim specimens. We heard about RCM through scientific publications as well as presence in conferences. We use many complementary microscopies wide-field fluorescence, TIRF, confocal point scanning and spinning disk, super-resolution microscopes such as: OMX (for Structured Illumination Microscopy) STED (Stimulated Emission Depletion Microscopy) and STORM (for Single-molecule Localization Microscopy). We also use correlative electron microscopy and fluorescence imaging platforms.”

Working with was a positive experience for Dr Pinotsi. “As a “young’’ spin-off company, is a dedicated team closely linked to academia. Communication was easily established. This has been beneficial not only for reporting of issues/problems or answering questions but also for exchanging suggestions and scientific ideas for experiments and possible product improvements. Before and during purchase, we were in direct contact with both the team and Nikon Switzerland. The latter offered a solution for installing the RCM as part of the entire STORM system.”

Speaking about the installation in Zurich,’s CEO, Peter Drent, says “We worked with the ScopeM team and Nikon Switzerland to configure this advanced super resolution system. ETH is a most prestigious research organisation and we are thrilled to have them select one of our pioneering, high sensitivity confocal systems.”

RCM system
RCM system in use at ScopeM at the ETH in Zurich
U2OS cells
U2OS cells immunostained for actin (purple) and Golgi apparatus (blue)
Confocal demo form image

See for yourself how we improve your experience

Request your
personalized demo

In about 45 minutes to an hour, our experts
show you how our products perform live.

Request your personalized demo

In about 45 minutes to an hour, our expert shows you how our products perform live. This way, you can see for yourself how we improve your live cell imaging experience! Fill out the form below and we will reach out to you to plan a demo.

RCM2’s next generation is here: RCM2.5! proudly presents its newest member to the family: 



Work more efficiently, save time and produce high contrast images of the best quality through the addition of a fifth laser, which allows you to extend over the Visible and Near-Infrared (NIR). Find out more!

See for yourself how we improve your experience

Request your personalized demo

In about 45 minutes to an hour, our experts show you how our products perform live.

Become a distributor

Contact a distributor

Contact us