the Dutch microscopy company
Who we are
Confocal.nl is a spin-off of the University of Amsterdam, founded by Erik Manders and Peter Drent. Eriks well-known contributions to the field of microscopy are the Manders’ coefficient for measurement of co-localization, Controlled Light Exposure Microscopy and Re-scan Confocal Microscopy. Peter has 25 years of experience in sales, marketing and development of (confocal) microscopes. Now Erik and Peter are teaming up to innovate confocal microscopy with the Re-scan Confocal Microscope, RCM.
Confocal.nl is aiming to innovate the microscopy industry with our plug-and-play feature microscopes including the re-scan invention. Our new RCM-microscope has an improved resolution and strongly improved sensitivity as compared to most confocal microscopes. It will be available as a highly affordable, customized device, which is ideal for labs with specific interests. As the product can be configured in many different ways enabling new types of applications we are open to target your specific needs.
The RCM is a standard confocal microscope extended with a re-scan detection unit. With a simple trick a resolution of 170nm can be achieved for any pinhole diameter. The pinhole is only needed for Z-sectioning. Since RCM has also a strongly improved sensitivity here is no need for high laser power, being more friendly for cells. At this moment RCM can work in multi-colour mode for different colour combinations and ratio-imaging. But it is our mission to go further by extending the spectral range into the IR for deep tissue imaging and real-time acquisition speed for monitoring highly dynamic processes. Applications like FRET, FRAP, pH, are Ca2+ are possible and many more biological applications are on the horizon.
The RCM unit is a plug-and-play box that can easily be connected via standard C-mount adapters to the microscope and camera. The laser light can be fed into the RCM unit via a single mode fibre connector. All standard connectors, no restrictions here!
For us this RCM project is extremely exciting from both a scientific and commercial point of view. The collaboration with universities is for our spin-off company key. As the product can be configured in many different ways enabling new types of applications we are open to target your specific needs. Please inform us your needs and contact us in case you would like to reserve a RCM unit for your own lab!
From September we will offer unique hands-on experiences in Amsterdam. Please register if you want to participate. We can also organize such a hands-on experience in your own laboratory! Please contact us if you have any further questions.